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April 22, 2026Clinical Case Reports0 citationsOpen Access

Coexistence of Medullary Thyroid Carcinoma and Bilateral Pheochromocytoma in MEN2A Syndrome: Atypical Presentation and Clinical Insights From a Case Report

JVJuan Carlos Vallejo-SotoHospital Universitario San Ignacio RGRogers Leonardo Baquero GarcíaHospital Universitario San Ignacio ÁCÁlvaro Eduardo Granados CalixtoFundación Universitaria de Ciencias de la Salud

Key Points

To explore the coexistence of medullary thyroid carcinoma and bilateral pheochromocytoma in a patient with MEN2A syndrome.
Examined clinical data of a patient with MEN2A syndrome exhibiting bilateral pheochromocytoma and medullary thyroid carcinoma.
Analyzed the impact of RET mutations on surgical decisions and management.
Emphasized the importance of lifelong monitoring for adrenal crises.
Bilateral pheochromocytomas appeared prior to medullary thyroid carcinoma diagnosis, suggesting atypical syndrome progression.
RET mutations influenced surgical strategy, demonstrating the need for aggressive management despite benign tumor characteristics.
Showed that ongoing surveillance is crucial for detecting potential hypertensive crises from late adrenal recurrences.

Abstract

ABSTRACT MEN2A may present with bilateral pheochromocytoma a decade before medullary thyroid carcinoma. This case highlights that high‐risk RET mutations must dictate surgical management regardless of benign cytology. Furthermore, it underscores the necessity of lifelong surveillance for late adrenal recurrences presenting as hypertensive crises.

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