ABSTRACT Marine fungi are known to produce natural products possessing significant therapeutic potential. Here, chemical exploration of a marine‐derived Aspergillus strain, coupled with comprehensive spectroscopic analyses (NMR spectroscopy and x‐ray diffraction) and chemical calculations, resulted in the isolation and identification of six aryl‐type compounds, including three new metabolites: aspergiterpenamine ( 1 ), norbisaboid ( 3 ), and 3’‐carboxy‐4’,7‐dihydroxyisoflavone ( 4 ). Notably, compound 1 features an unprecedented benzylamine moiety fused to a bisabolane sesquiterpene scaffold, while compound 3 is distinguished by the elimination of three carbons from the isopropyl side chain of its terpene skeleton, which expands the structural diversity of aryl‐containing natural products.
Chen et al. (Wed,) studied this question.