Intracellular TRPM7-Mediated Zn 2+ Release: A Novel Pyroptotic Axis in Myocardial Ischemia-Reperfusion Injury

Key Points

• This research aims to explore the role of TRPM7-mediated zinc release in inducing pyroptosis during myocardial ischemia-reperfusion injury.
• Utilized acute myocardial ischemia-reperfusion injury model in vivo.
• Inhibited TRPM7 activity to assess effects on zinc release and pyroptosis.
• Measured inflammatory markers and cell death associated with pyroptosis.
• TRPM7 inhibition significantly reduced Zn2+ release and pyroptosis markers.
• Decreased myocardial injury observed in TRPM7-inhibited groups (p<0.01).
• Lower levels of inflammatory cytokines were noted in treated groups compared to controls.