What question did this study set out to answer?

To evaluate how maternal body mass index affects the performance of non-invasive prenatal testing.

April 24, 2026Open Access

Impact of Maternal Body Mass Index (BMI) on the Performance of Non‐Invasive Prenatal Testing (NIPT)

KVKristína ValovičováMasaryk University MPMarike Polak SOSophie OttemaErasmus MC

Key Points

To evaluate how maternal body mass index affects the performance of non-invasive prenatal testing.
Observational study analyzing NIPT performance in relation to maternal BMI.
Assessment of fetal fraction (FF) levels among different BMI groups.
Recommendations for pre-test counseling and timing of NIPT administration.
NIPT shows suboptimal performance in obese women due to low fetal fraction.
Advisable strategies include re-sampling and postponing NIPT until after 12 weeks of gestation.

Abstract

Our results indicate that NIPT performs suboptimal in obese women due to too low FF. This should be addressed during pre-test counseling and strategies such as re-sampling instead of re-working, or postponing NIPT until after 12 weeks of gestation may be advisable.

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