Abstract Studying chondrocyte division in fish has great biological significance in obtaining knowledge helpful for cartilage regeneration. This study focuses on the staged description of the chondrocytes in brachial cartilage in silver carp. Morphological analysis of different stages of chondrocyte division until yield chondrocyte progeny described and discussed the morphological criteria of dividing chondrocytes in brachial cartilage of carp and compared with the known similar features and their indications. The chondrocyte maintains the nuclear membrane during typical cell division. Nuclear changes of the dividing chondrocyte include chromatin condensation (chromatin condensation stage), nuclear indentation (initial lobulation stage), lobulation (lobulation stage), and lobular separation (separation stage). During division, chromatin underwent incomplete condensation that unable to form defined chromosomes. Dividing chondrocytes remained active secretory cells that developed an extensive membranous system of rough endoplasmic reticulum. Chondrocytes exhibited secretory vesicles and cellular extrusion, which probably participate in matrix formation. Chondrocyte division yields chondrocyte progeny located in hemi-circular lacunae. The nuclear-cytoplasmic ratio and the number of chondrocytes at different stages statistically analyzed. Understanding the molecular pathways that regulate atypical chondrocyte division in aquatic species is important to identify a different strategy for propagating chondrocytes and for delivering a potentially useful approach to enhancing cartilage repair and tissue engineering.
Soha soliman (Tue,) studied this question.