Four-Week Low-Frequency Right Dorsal Lateral Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation Versus Low-Dose Sertraline in Treatment-Naïve Generalized Anxiety Disorder: A Randomized, Single-Blind Study

Key Points

• The study aims to compare the efficacy of low-frequency rTMS and low-dose sertraline in reducing anxiety symptoms in patients with generalized anxiety disorder.
• Randomized, single-blind design
• Participants were treatment-naïve patients with generalized anxiety disorder
• Monotherapy with rTMS or sertraline for 4 weeks
• rTMS monotherapy reduced anxiety symptoms more than low-dose sertraline monotherapy during the 4-week period
• Combination therapy with rTMS achieved efficacy comparable to sertraline monotherapy
• Further confirmatory trials are necessary to validate these findings.