Does the coronary artery calcium score improve risk prediction of CHD compared to the polygenic risk score in middle-aged to older adults?
Coronary artery calcium scoring provides superior risk discrimination and reclassification for coronary heart disease compared to polygenic risk scores when added to traditional risk factors.
In 2 cohorts of middle-aged to older adults from the US and the Netherlands, the coronary artery calcium score had better discrimination than the polygenic risk score for risk prediction of CHD. In addition, the coronary artery calcium score but not the polygenic risk score significantly improved risk discrimination and risk reclassification for CHD when added to traditional risk factors.
Khan et al. (Tue,) studied this question.