Does the -174G/C Interleukin-6 polymorphism influence postoperative Interleukin-6 levels and postoperative atrial fibrillation?
The -174G/C Interleukin-6 polymorphism is associated with postoperative inflammation and atrial fibrillation, suggesting a genetic and inflammatory basis for this complication.
The -174G/C Interleukin-6 promoter gene variant appears to modulate the inflammatory response to surgery and to influence the development of postoperative AF. These data suggest an inflammatory component of postoperative atrial arrhythmias and a genetic predisposition to this complication.
Gaudino et al. (2003) studied this question.
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