These four articles collectively point to a core insight: chemistry is not merely a tool for biosensors, but rather their intrinsic determinant. The performance of each sensor -sensitivity, specificity, response speed, and stability-is ultimately governed by the controllability, reversibility, and efficiency of the underlying chemical reactions. More importantly, these studies all follow a similar structure-activity relationship paradigm: by systematically varying chemical parameters and precisely measuring their impact on sensor performance, researchers are advancing the development of biosensors from a "trial-and-error" approach toward " rational design". Thus, within the interdisciplinary field of biosensors, chemistry serves as the converter between the biological world and physical signals, and as the ultimate foundation for achieving high-precision and high-reliability detection.
Rui Wang (Thu,) studied this question.