Longitudinal Cortical Surface Signatures Distinguish Neuromyelitis Optica Spectrum Disorder from Multiple Sclerosis

Key Points

• This research aims to identify specific cortical surface changes that can differentiate neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS).
• Longitudinal analysis of cortical surface regions was performed.
• Distinct reductions in specific cortical areas were measured over time.
• Comparative metrics for NMOSD and MS were assessed.
• Longitudinal reductions in cortical regions distinctively separated NMOSD from MS.
• Findings support the potential of using cortical metrics to indicate disease activity.