The role and mechanism of miR-875-3p in targeting SLC39A14 to regulate ferroptosis in osteosarcoma proliferation, migration, and invasion

Key Points

• This research aims to explore how miR-875-3p affects osteosarcoma growth and aggressiveness through SLC39A14.
• Investigation of the interaction between miR-875-3p and SLC39A14
• Analysis of the effects on ferroptosis in osteosarcoma cells
• Evaluation of proliferation, migration, and invasion in vitro
• miR-875-3p significantly reduced ferroptosis, promoting osteosarcoma cell proliferation.
• Targeting SLC39A14 with miR-875-3p enhanced migration and invasion capabilities of osteosarcoma cells.
• The study suggests targeting the miR-875-3p/SLC39A14 axis for potential therapeutic interventions.