Abstract Dyslipidemia refers to a variety of inherited and acquired illnesses, in which serum lipid and lipoprotein levels are abnormal. It is a frequent condition worldwide. Dyslipidemia does not usually cause life-threatening symptoms. However, this underlying pathology can lead to major illnesses, including vascular disorders, especially cardiovascular and cerebrovascular disease, which can lead to mortality. Statins and fibrates remain the most used anti-hyperlipidemic drugs for the treatment of high blood cholesterol and triglycerides, respectively, at the cost of significant muscular and hepatic adverse effects. It is vital to develop an effective, safe, and cost-effective treatment to reduce the morbidity and mortality rates associated with this illness. This review aims to deepen the understanding of dyslipidemia through the perspective of Unani medicine, an ancient healing system recognized by the World Health Organization. In addition, it investigates therapeutic pathways within the Unani medical framework by integrating ancient knowledge with modern viewpoints. It examines Unani scholars’ interpretation of dyslipidemia ( Khalal Shaḥmiyyāt al-Dam ), exploring their perspectives on its causes, pathogenesis, and treatment strategies. Unani scholars have extensively documented the etiopathogenesis, risk factors, and management of dyslipidemia, with a particular emphasis on personalized interventions grounded in Unani pathological concepts. Recent preclinical and clinical studies have demonstrated the effectiveness of these interventions comparable to standard treatments. This review enhances understanding of dyslipidemia pathogenesis according to Unani principles and promotes a holistic management approach. It may serve as a reference for future research in this field.
Khan et al. (Wed,) studied this question.