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December 7, 2004Circulation

After 10+/-3 years of RVP, CCAVB adults had significantly higher intra-LV asynchrony (59+/-18 vs 19+/-9 ms, P<0.001) and lower exercise performance (123+/-24 vs 185+/-39 W, P<0.001) compared to controls.

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Why the study?

Does chronic right ventricular apical pacing induce detrimental ventricular remodeling and reduce exercise capacity in adults with congenital complete heart block compared to healthy controls?

Population

23 adults with complete congenital atrioventricular block, mean age 24+/-3 years, with a DDD transvenous…

Comparison

Chronic right ventricular apical pacing for at… vs 30 matched healthy control subjects, and…

Design

Cohort

Follow-up

10+/-3 years

Authors

JTJean‐Benoît ThamboPBPierre BordacharSGStéphane Garrigue

Discussion

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Overview

Long-term RVP may reduce exercise capacity in CCAVB; hypothesis-generating for alternative pacing strategies in this population.

Structured PICO

Does chronic right ventricular apical pacing induce detrimental ventricular remodeling and reduce exercise capacity in adults with congenital complete heart block compared to healthy controls?

P
Population
23 adults with complete congenital atrioventricular block (CCAVB), mean age 24+/-3 years, with a DDD transvenous pacemaker, and 30 matched healthy control subjects.
I
Intervention
Chronic right ventricular apical pacing (RVP) for at least 5 years (mean 10+/-3 years)
C
Comparator
30 matched healthy control subjects, and pre-implantation baseline
O
Outcome
Echocardiographic measures of ventricular dyssynchrony and remodeling (intra-LV asynchrony, delayed longitudinal contraction, wall-motion delay, wall thickness ratio, LV end-diastolic diameter), cardiac output, and exercise performancesurrogate

Prolonged right ventricular apical pacing in adults with congenital complete heart block is associated with significant left ventricular dyssynchrony, adverse remodeling, and reduced exercise capacity.

Cite This Study

Thambo et al. (2004) studied this question.

synapsesocial.com/papers/69f3eeb1dc238f8197799919https://doi.org/10.1161/01.cir.0000150336.86033.8d
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