The atherogenic index of plasma independently predicted coronary artery disease severity, with higher levels significantly increasing the odds of multivessel disease (OR 1.700).
Cohort (n=2,561)
No
Does a higher atherogenic index of plasma correlate with greater coronary artery disease severity in hospitalized patients with CAD?
The atherogenic index of plasma is significantly associated with angiographic CAD severity, suggesting its potential utility as a simple marker for risk stratification.
Effect estimate: OR 1.700 (95% CI 1.160-2.491)
p-value: p=0.007
Background: The atherogenic index of plasma (AIP), calculated from triglyceride and high-density lipoprotein cholesterol levels, is associated with atherosclerosis and coronary artery disease (CAD). However, evidence concerning the impact of the AIP on CAD severity remains limited. This study aims to assess the correlation between AIP and the severity of CAD. Methods: This study included 19,929 hospitalized participants diagnosed with CAD. After excluding participants with missing data, aged >75 years, or diagnosed with chronic kidney disease or cancer, a total of 2561 individuals were included. The 2561 participants were divided into three AIP tertile groups: AIP1 (AIP <0.016, n = 854), AIP2 (0.016 ≤ AIP < 0.216, n = 853), and AIP3 (AIP ≥0.216, n = 854). In this study, CAD severity was determined by the count of coronary arteries exhibiting stenosis of 50% or greater. Multivessel CAD was defined as ≥50% stenosis in two or more major coronary arteries. The relationship between AIP and CAD severity was assessed using logistic regression models. Results: Results indicate that the AIP independently predicts CAD severity, with an odds ratio of 1.700 (95% confidence interval (CI): 1.160–2.491; p = 0.007). The AIP3 group demonstrated a significantly higher risk of multivessel CAD compared to the AIP1 group (odds ratio (OR), 1.441; 95% CI: 1.124–1.848; p = 0.004), particularly in patients without diabetes mellitus (OR, 1.421; 95% CI: 1.030–1.962; p = 0.033). Conclusions: The AIP was significantly associated with CAD severity, suggesting that it could be a convenient and valuable marker for severity stratification in patients with CAD in clinical practice.
Wang et al. (Wed,) conducted a cohort in Coronary Artery Disease (CAD) (n=2,561). Atherogenic index of plasma (AIP) vs. Lower AIP levels was evaluated on Coronary artery disease severity (multivessel CAD) (OR 1.700, 95% CI 1.160-2.491, p=0.007). The atherogenic index of plasma independently predicted coronary artery disease severity, with higher levels significantly increasing the odds of multivessel disease (OR 1.700).