What question did this study set out to answer?

The aim is to evaluate the effects of GalNAc-siXDH in reducing hyperuricaemia and associated renal injuries.

May 6, 20260 citations

Targeted Knockdown of Hepatic XDH via GalNAc-siRNA Alleviates Hyperuricaemia and Renal Injury in UOX-/- Mice.

RLR LiSun Yat-sen University YLY H LiSun Yat-sen University CZC. Y. ZhangSun Yat-sen University

Key Points

The aim is to evaluate the effects of GalNAc-siXDH in reducing hyperuricaemia and associated renal injuries.
Used UOX-/- mice as a hyperuricaemia model.
Administered GalNAc-siXDH to reduce hepatic XDH levels.
Measured serum urate levels and assessed renal damage.
GalNAc-siXDH significantly reduced serum urate levels.
Treatment alleviated renal inflammation and fibrosis.

Abstract

) hyperuricaemia mouse model. Our results demonstrated that GalNAc-siXDH can reduce serum urate levels, and alleviate renal damage including inflammation and fibrosis, indicating that GalNAc-siXDH is a potential therapeutic candidate for the treatment of hyperuricaemia.

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