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November 11, 2019Circulation442 citationsOpen Access

Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

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ABAlexander G. BickJPJames P. PirruccelloGGGabriel K. Griffin

Key Points

  • This research aims to investigate whether genetic deficiencies in IL-6 signaling can lower cardiovascular risk in individuals with clonal hematopoiesis (CHIP).
  • Examined the association between clonal hematopoiesis and cardiovascular disease risk
  • Utilized genetic analysis to identify IL-6 signaling deficiencies among CHIP carriers
  • Explored the impact of reduced IL-6 signaling on cardiovascular health outcomes.
  • CHIP is associated with increased risk of incident cardiovascular disease (CVD)
  • In CHIP carriers with genetic IL-6 signaling deficiency, the risk of developing CVD was significantly reduced (P=0.036).

Abstract

BACKGROUND: . In humans, CHIP associates with prevalent myocardial infarction. In mice, CHIP accelerates atherosclerosis and increases IL-6/IL-1β expression, raising the hypothesis that IL-6 pathway antagonism in CHIP carriers would decrease cardiovascular disease (CVD) risk. METHODS: p.Asp358Ala. RESULTS: =0.036). CONCLUSIONS: CHIP is associated with increased risk of incident CVD. Among carriers of large CHIP clones, genetically reduced IL-6 signaling abrogated this risk.

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Cite This Study

Bick et al. (2019) studied this question.

synapsesocial.com/papers/69fc05063a0f4cc134c8ee27https://doi.org/10.1161/circulationaha.119.044362
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