A method for the determination of residues of 19 veterinary drugs (sulfonamides, coccidiostats, NSAIDs, fluoroquinolones, macrolides, lincosamides, and tetracyclines) in environmental objects using high-performance liquid chromatography with tandem mass spectrometry detection is developed. A universal sample preparation method using liquid-liquid extraction is proposed for analyzing soil, water, and plant samples. The accuracy of the analysis is ensured by the addition of isotopically labeled standards. The developed approach enables the simultaneous determination of residues of enrofloxacin, ciprofloxacin, ofloxacin, oxytetracycline, doxycycline, tetracycline, sulfamethazine, sulfamethoxazole, sulfadiazine, trimethoprim, erythromycin, clarithromycin, tylosin, tilmicosin, spiramycin, diclofenac, lasalocid, maduramicin, and lincomycin in environmental objects with minimal sample preparation. The lower limit of detection for most analytes does not exceed 5 μg/L (μg/kg). Analysis time is 30 min.
Nekrasov et al. (Wed,) studied this question.