Introduction/Objective: Carica papaya L. (family Caricaceae), commonly known as papaya, is a nutrient-rich species valued for its varied phytochemical and pharmacological properties. The review focuses on the non-edible parts of papaya, particularly the peel, which constitutes approximately 12% of the fruit's total weight. Methods: A literature survey was conducted using online scientific databases up to 2025, including PubMed, SciFinder, Web of Science, Science Direct, Wiley Online, ResearchGate, Google Scholar, and Scopus. Results: Papaya peel is rich in secondary metabolites and bioactive compounds, contributing to its significant pharmacological activities, including antioxidant, antimicrobial, and anticancer properties. Additionally, papaya peel can be used as a food additive, for wastewater treatment, enzyme production, and biofuel generation. Discussion: The diverse uses of papaya peel make it a promising resource for various industrial and pharmaceutical applications. Conclusion: This paper provides a comprehensive overview of the bioactive compounds found in papaya peel, their health benefits, and the development of therapeutic agents and other valuable applications.
Bhattacharyya et al. (Thu,) studied this question.