Two periods of high-intensity interval training, spaced one year apart, significantly improved myocardial function in middle-aged adults with metabolic syndrome compared to medical treatment alone (p=0.002).
RCT
Do repeated periods of high-intensity interval training improve myocardial function in middle-aged adults with metabolic syndrome?
Two periods of high-intensity interval training spaced a year apart significantly improved myocardial function in middle-aged adults with metabolic syndrome compared to medical therapy alone.
p-value: p=0.002
BACKGROUND: One program of exercise training is useful to improve myocardial function in patients with cardiovascular disease (CVD) but not in patients with CVD risk factors. However, it is unknown whether repeated periods of high-intensity interval training (HIIT) can reverse the progressive myocardial dysfunction observed in patients with metabolic syndrome (MetS). We aimed to follow MetS patients for 16 months and determine the effect of two periods of HIIT, separated by a year, on their myocardial function. METHODS: ), and MetS components were assessed at baseline, after the first HIIT period (4 months), and one year later, after the second HIIT period. Variables were analyzed following the intention-to-treat analysis principle using linear mixed model. RESULTS: improved only in the HIIT group (group*time p = 0.002), while ejection fraction and MetS z-score changes were not different between groups (group*time p = 0.964 and p = 0.419, respectively). CONCLUSIONS: Among middle-aged adults receiving medical treatment for MetS, the addition of two HIIT periods, spaced one year apart, led to significant improvements in myocardial function, that were not observed in the control group receiving medical treatment alone. CLINICAL TRIALS NUMBER: NCT06262256.
Ortega et al. (Fri,) conducted a rct in Metabolic syndrome (MetS). High-intensity interval training (HIIT) vs. Medical treatment alone was evaluated on Myocardial function (p=0.002). Two periods of high-intensity interval training, spaced one year apart, significantly improved myocardial function in middle-aged adults with metabolic syndrome compared to medical treatment alone (p=0.002).