What question did this study set out to answer?

This study investigates how attenuated PRV immunization can protect against CNS injury caused by PRV infection.

May 8, 2026Open Access

PRV-delgE/gI/TK immunization preserves blood–brain barrier integrity and limits CNS injury following intracerebral PRV challenge

Key Points

This study investigates how attenuated PRV immunization can protect against CNS injury caused by PRV infection.
Administered PRV-delgE/gI/TK immunization pre-challenge.
Evaluated blood-brain barrier integrity post-intracerebral PRV challenge.
Assessed CNS injury outcomes following infection.
Enhanced preservation of blood-brain barrier compared to control (p<0.05).
Significantly reduced CNS injury markers post-immunization (p<0.01).
Demonstrated efficacy of immunization strategy in neurotropic PRV infection.

Abstract

evidence that attenuated PRV immunization can protect against PRV-induced CNS injury and offer important insights for improving prevention strategies against neurotropic PRV infection.

PRV-delgE/gI/TK immunization preserves blood–brain barrier integrity and limits CNS injury following intracerebral PRV challenge

Key Points

Abstract

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