Abstract Background: Autism spectrum disorder (ASD) is a wide spectrum of neurodevelopmental disorders involving social cognitive deficiency, communicative disorders, repetitive behaviors, and confined interests. The specific mechanism of ASD has yet to be identified; however, multiple genetic, environmental, and immunologic factors play non-negligible roles in its etiology. Objectives: This study aimed to identify the possible correlation between vitamin E (VE), vitamin D3, and autism disorder, as well as the effects of gender and their levels. Materials and Methods: This study consists of 150 participants, divided into two groups: 100 ASD children and a control group (50), their age range is 4–10 years. Results: This study showed decreased levels of VE in ASD children when compared with controls ( P < 0.01–0.05). Significant variances were seen between VE and ASD ( P < 0.001). No influence of gender on VE levels; also, there were no significant variations in levels of Vit. D3 levels compared with the Control, also no influence of gender on the level of D3. There is a highly significant difference between children with ASD and controls, and there is no influence of gender on VE levels, so we can utilize VE concentration as an indicator of ASD. Conclusion: According to the results of thisstudy, vitamin D3 levels in healthy individuals are generally lower compared with the normal range, and as a result, they are close to the values for ASD children. As a result of the low concentration of vitamin D3, we are incapable of using it as a marker for ASD or other ailments.
Sahib et al. (Thu,) studied this question.