Widespread Prostate Cancer Osseous Metastases: Negative on 18 F-Piflufolastat PET but Positive on 18 F-Fluciclovine PET

Key Points

• This report aims to highlight the differences in PET imaging results for prostate cancer metastases based on PSMA expression.
• Case presentation of an 84-year-old man diagnosed with prostate cancer.
• Analysis of PET imaging results using both piflufolastat and fluciclovine.
• Comparison of avidity and nonavidity of metastases in relation to PSMA expression.
• PET imaging with 18F-Piflufolastat was negative for metastases.
• PET imaging with 18F-Fluciclovine was positive for metastases.
• Findings indicate the presence of metastases that do not express PSMA.