Nanotechnology in pharmacy has driven major advancements in drug delivery systems by enabling targeted delivery, improving solubility and bioavailability, and protecting active compounds from biological degradation. Among the critical factors influencing nanoparticle performance, polymer selection plays a central role in determining physicochemical characteristics and pharmacokinetic behavior. This study reviews and analyzes the effects of different polymer types and combinations on nanoparticle properties based on articles published between 2020 and 2025 obtained from major scientific databases. The findings demonstrate that polymer type and combination significantly affect particle size, polydispersity index, zeta potential, morphology, entrapment efficiency, and drug loading capacity. Combination polymer systems generally produce smaller and more homogeneous nanoparticles, improved stability, higher drug encapsulation efficiency, and more favorable spherical and compact morphologies compared to single-polymer systems. Furthermore, polymer-based nanoparticles markedly enhance in vivo bioavailability, with the highest increases observed in combination polymer formulations. Overall, the appropriate selection and combination of polymers are crucial for optimizing nanoparticle characteristics and improving therapeutic performance, making combination polymer systems a promising strategy in advanced drug delivery applications.
Ainurofiq et al. (Fri,) studied this question.
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