A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer

Key Points

• This research aims to identify tumor-intrinsic mechanisms of immune evasion in microsatellite stable colorectal cancer (CRC).
• Investigated T-cell-mediated cytotoxicity in CRC
• Examined the role of the WICC-NOTUM axis
• Proposed NOTUM as a therapeutic target for overcoming immune resistance
• Identified a significant tumor-intrinsic mechanism of immune resistance
• Demonstrated that targeting the NOTUM program may enhance immunotherapy effectiveness
• Showed the WICC-NOTUM axis influences T-cell responses in CRC.