Sex-Specific Modulation of Drug Metabolizing Enzymes, Transporters, and Pro-Inflammatory Cytokines by Arsenic Trioxide in C57Bl/6 Mice

Key Points

• This research aims to explore how arsenic trioxide affects drug metabolizing enzymes and inflammatory cytokines differently in male and female mice.
• C57Bl/6 mice were utilized for the study.
• Arsenic trioxide was administered to assess its effects on drug metabolism and inflammation levels.
• Analysis included measurement of enzyme activity and cytokine levels.
• Arsenic trioxide caused a significant modulation of drug metabolizing enzymes in a sex-specific manner.
• Female mice exhibited higher levels of certain pro-inflammatory cytokines post-treatment compared to male mice.
• The findings imply potential differences in therapeutic efficacy and toxicity based on sex.