Synergistic Effects of a Methyl Pyropheophorbide–Cystamine–Ferrocenecarboxylic Acid Ternary Conjugate on Targeted Regulation of Tumor Hypoxia and Immune Suppression for Remodeling the Tumor Immune Microenvironment

Key Points

• This research aims to investigate the effects of a ternary conjugate on tumor hypoxia and immune suppression during immunotherapy.
• Combined HCFCMP with immune checkpoint blockade therapy.
• Evaluated primary tumor growth and distant tumor progression effects.
• Measured changes in the tumor immune microenvironment.
• HCFCMP significantly inhibits primary tumor growth.
• The ternary conjugate suppresses distant tumor progression effectively.
• Improved the immunotherapeutic response rate significantly.