February 15, 2018Open Access

Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL

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Abstract

NK-cell phenotype. In addition to direct inhibition of NK cells by the malignant B cell, suppression of NK cells can occur indirectly by PD-L1/PD-L2-expressing TAMs. The mechanism is more prominent in cHL than DLBCL, which may contribute to the clinical sensitivity of cHL to PD-1 blockade.

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Vari et al. (Thu,) studied this question.

synapsesocial.com/papers/6a01254c2ff633f365783f23 https://doi.org/https://doi.org/10.1182/blood-2017-07-796342

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