Conventional dietary counseling for noncommunicable diseases (NCDs) frequently has low adherence due to a “one-size-fits-all” approach. Precision nutrition provides an evidence-based alternative by personalizing guidance to individuals’ biology and lifestyle variables. The purpose of the present study was to synthesize scholarly material on the efficacy of the personalized nutrition (PN) counseling technique and to identify the needs for clinical implementation. We prioritized data from randomized controlled trials (RCTs) retrieved from PubMed, Scopus, and Web of Science, with an emphasis on metabolic phenotyping and omics-based therapies. Pioneering RCTs show that PN counseling tailored to metabolic phenotypes may benefit insulin sensitivity and cardiovascular risk factors. Conversely, recent trials indicate that current genomic risk scores alone may not lead to superior weight loss, highlighting the need for multiomicron integration. While the lack of ethnic diversity remains a limitation, newer studies are beginning to address this with more inclusive cohorts to enhance generalizability. In conclusion, PN’s unique insights have the potential to completely transform dietary counseling. To overcome feasibility issues in low- and middle-income nations, scalable models and inexpensive assessment methods must be developed for widespread clinical implementation.
Rai et al. (Fri,) studied this question.