A high BCIS-CHIP score (≥5) was an independent predictor of 1000-day mortality (HR 2.282; 95% CI 1.454-3.583) and heart failure events in patients with ischemic acute heart failure.
Cohort (n=1,655)
Does a high BCIS-CHIP score predict 1000-day mortality and HF events in patients with ischemic acute heart failure?
The BCIS-CHIP score is a valuable tool for risk stratifying patients with ischemic acute heart failure, with high scores predicting significantly worse 1000-day mortality and HF events.
Effect estimate: HR 2.282 (95% CI 1.454-3.583)
BACKGROUND: The characteristics of acute heart failure (AHF) vary according to ischemic and non-ischemic etiology. Risk stratification of these characteristics by etiology is a pressing issue. METHODS AND RESULTS: A total of 1655 AHF patients were analyzed. Patients were divided into two groups by their etiology ischemia (n = 693) and non-ischemia (n = 962) groups, and the ischemia group was further divided into three groups according to their British Cardiovascular Intervention Society (BCIS)-complex high risk indicated percutaneous coronary intervention (CHIP) score low-score (Q1, BCIS-CHIP ≤2, n = 203), middle-score (Q2, 3 ≤ BCIS-CHIP≤4, n = 229), and high-score (Q3, BCIS-CHIP ≥5, n = 261). A multivariate logistic regression model showed that male sex odds ratio (OR): 2.286, 95% confidence interval (CI): 1.785-2.926 and presence of chronic kidney disease (OR: 1.506, 95%CI: 1.197-1.895) were independently associated with ischemic etiology. Kaplan-Meier curve analysis showed that HF events within 1000 days were significantly less frequent in the ischemia group than in the non-ischemia group, and that the survival and event-free rates were significantly lower in the high-BCIS-CHIP score group than in the other two groups. A Cox regression model indicated that a high-BCIS-CHIP score was an independent predictor of 1000-day mortality hazard ratio (HR): 2.282, 95%CI: 1.454-3.583 and HF events (HR: 1.968, 95%CI: 1.429-2.710). CONCLUSION: Ischemic AHF was associated with male sex and chronic kidney disease, and the BCIS-CHIP score is valuable for risk stratification of ischemic AHF patients.
Sawatani et al. (Sun,) conducted a cohort in Acute heart failure (n=1,655). High BCIS-CHIP score (≥5) vs. Low and middle BCIS-CHIP scores (≤4) was evaluated on 1000-day mortality (HR 2.282, 95% CI 1.454-3.583). A high BCIS-CHIP score (≥5) was an independent predictor of 1000-day mortality (HR 2.282; 95% CI 1.454-3.583) and heart failure events in patients with ischemic acute heart failure.