to mammals have revealed cell-autonomous and systemic DDR mechanisms that orchestrate adaptive responses that augment maintenance of the aging organism amid gradually accumulating DNA damage.

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DNA damage responses and p53 in the aging process | Synapse

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Ou et al. (Wed,) studied this question.

synapsesocial.com/papers/6a033358d2181737fb9e2eb2 https://doi.org/https://doi.org/10.1182/blood-2017-07-746396

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1<i>Caenorhabditis elegans</i> p53: Role in Apoptosis, Meiosis, and Stress Resistance2001 · 469 citations
2Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia1981 · 276 citations
3The genetic and molecular basis of Fanconi anemia2008 · 209 citations
4The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining1986 · 184 citations
5The p53 network: cellular and systemic DNA damage responses in aging and cancer2012 · 448 citations

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1<i>Caenorhabditis elegans</i> p53: Role in Apoptosis, Meiosis, and Stress Resistance2001 · 469 citations
2Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia1981 · 276 citations
3The genetic and molecular basis of Fanconi anemia2008 · 209 citations
4The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining1986 · 184 citations
5The p53 network: cellular and systemic DNA damage responses in aging and cancer2012 · 448 citations