Why the study?
Does TAVR improve survival compared to SAVR in low-risk patients?
Population
Low-risk patients
Comparison
TAVR vs SAVR
Design
Meta-analysis of reconstructed time-to-event data
Key result
SAVR appeared to be associated with improved survival beyond 2 years compared to TAVR in low-risk patients, but this benefit was observed only in propensity score-matched studies and not in RCTs.
Authors
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SAVR survival benefit in low-risk patients should not yet change practice; leaves open need for extended RCT follow-up to resolve observational-RCT discordance.
Meta-Analysis
Does TAVR improve survival compared to SAVR in low-risk patients?
p-value: p=0.398
In low-risk patients, SAVR may be associated with improved midterm survival compared to TAVR, though this finding is currently driven by observational data rather than randomized trials.
Sá et al. (2023) conducted a meta-analysis in Aortic valve disease in low-risk patients. Transcatheter Aortic Valve Replacement (TAVR) vs. Surgical Aortic Valve Replacement (SAVR) was evaluated on Survival (p=0.398). SAVR appeared to be associated with improved survival beyond 2 years compared to TAVR in low-risk patients, but this benefit was observed only in propensity score-matched studies and not in RCTs.