Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery

Key Points

• This research aims to investigate the occurrence of neuroepithelial tumors following the delivery of an AAV vector via the intracisternal route.
• Conducted a randomized trial analyzing tumor incidence post AAV vector delivery
• Monitored integration events in neural tissues
• Assessed clinical outcomes and any adverse effects.
• A higher incidence of neuroepithelial tumors observed in AAV group compared to control (p<0.05)
• Integration sites identified predominantly in neural progenitor cells
• Long-term follow-up indicates persistent tumor growth with associated neurological deficits.