Over the past several decades, there has been increasing interest in sensory systems based on the surface plasmon resonance (SPR) phenomenon for applications in biotechnology, medicine, and veterinary science. The study provides a comprehensive analysis of modern SPR sensor configurations, classified by modulation types and detection methods. The influence of substrate materials on sensor sensitivity was considered. The potential of polymer chips (PDMS, PMMA) for the disposable and portable sensors was explored. Particular attention was paid to SPR imaging methods and polarization contrast systems. The advancement of SPR imaging methods opens new frontiers for fundamental biology, drug screening, and medical diagnostics by providing spatial and mechanical resolution of complex molecular processes. The application of SPR technologies in medicine and veterinary science was systematized. Particular attention was given to the PLASMON series instruments developed at the V.E. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine in last decades. Their evolution from single-channel prototypes based on the Kretschmann configuration to modern multichannel systems with differential measurement modes, ensuring precise real-time extraction of optical parameters, was addressed. The integration of PLASMON devices with cutting-edge nanotechnology and imaging techniques in next-generation universal diagnostic platforms was discussed.
Samoylov et al. (Fri,) studied this question.