This scientific article provides a comprehensive and in-depth analysis of the causes of weakened immunity, its underlying mechanisms, and its impact on the human body from the perspectives of modern immunology, physiology, and pathophysiology. The immune system is considered a complex biological defense mechanism responsible for recognizing and eliminating viruses, bacteria, fungi, parasites, and other foreign agents while maintaining the internal homeostasis of the body. The study thoroughly examines the physiological foundations of innate and acquired immunity, the mechanisms of immune responses, and the role of immune cells such as T-lymphocytes, B-lymphocytes, macrophages, and natural killer cells. Particular attention is given to the interaction between the immune, nervous, and endocrine systems in maintaining the body’s protective functions. The article analyzes the major factors contributing to immune suppression, including chronic stress, sleep deprivation, physical inactivity, poor nutrition, vitamin and micronutrient deficiencies, harmful habits, and adverse environmental conditions. Special emphasis is placed on the role of stress hormones, particularly cortisol, in suppressing lymphocyte activity and weakening immune responses. Furthermore, the effects of chronic diseases such as diabetes mellitus, obesity, and cardiovascular disorders on immune system function are discussed in detail. It is demonstrated that weakened immunity increases susceptibility to infectious diseases, delays recovery processes, and contributes to chronic inflammatory conditions. The article also highlights that prolonged immune dysfunction may increase the risk of autoimmune disorders and oncological diseases. Preventive strategies aimed at strengthening immunity, including healthy lifestyle habits, balanced nutrition, regular physical activity, and stress management, are extensively discussed. In conclusion, weakened immunity is identified as a significant pathophysiological factor that negatively affects all body systems and substantially reduces overall health and quality of life.
Muhammaddiyor Kuziboyevich Nishonov (Thu,) studied this question.