The aim of the present study was to investigate serum albumin (ALB) levels in patients with type 2 diabetes following different exercise protocols and to examine its association with body composition as a factor related to muscle atrophy. In this pre-test/post-test clinical trial, 60 women with type 2 diabetes (aged 48–58 years) were selected and randomly assigned to resistance training (RT), endurance training (ET), combined training (CT), or control (CO) groups. The exercise interventions were conducted for 8 weeks, three sessions per week. Multivariate analysis of variance (MANOVA) was used to examine differences between groups, and Pearson’s correlation analysis was performed to assess the relationships between albumin and SMM, FMS, and BMI indices. All exercise modalities significantly improved anthropometric and metabolic outcomes compared with control (P < 0.05). Combined training (CT) produced the greatest reductions in body weight (−6.99 ± 1.69 kg), BMI (−3.06 ± 0.20 kg/m 2 ), fasting blood glucose (−24.16 ± 7.15 mg/dL), and HbA1c (−2.35 ± 0.84%; all P < 0.001). Resistance training (RT) induced the largest increase in skeletal muscle mass (+1.92 ± 0.83 kg), whereas endurance training (ET) resulted in the greatest reduction in fat mass percentage (−1.73 ± 1.32%). albumin levels increased significantly in all exercise groups compared to control (P < 0.001), with the greatest increase observed in the combined training group (from 4.27 ± 0.62 to 5.73 ± 0.88 g/dL). However, this increase in albumin was not significantly associated with changes in skeletal muscle mass (SMM) or fat mass percentage (FMS). Eight weeks of resistance training (RT), endurance training (ET), and combined training (CT) improve anthropometric indices and metabolic markers in women with type 2 diabetes, with each modality conferring distinct benefits. These interventions also lead to increased serum albumin (ALB) levels. However, this increase does not appear to be associated with changes in skeletal muscle mass (SMM) or reductions in fat mass percentage (FMS).
Ramezani et al. (Fri,) studied this question.