Multi-Organ Crosstalk in HFpEF: Reframing a Cardiac Syndrome as a widespread Systemic Disease

Key Points

• This research investigates how heart failure with preserved ejection fraction (HFpEF) interacts with other organ systems, treating it as a systemic condition rather than a localized cardiac issue.
• Analyzed multi-organ interactions in patients diagnosed with HFpEF.
• Examined physiological markers across various organ systems to assess systemic involvement.
• Conducted longitudinal assessments to track changes over time.
• Demonstrated significant inflammatory markers linked to HFpEF across multiple organs, with a prevalence of 70%.
• Identified at least three major system interactions, indicating a shift in understanding HFpEF as systemic rather than isolated to the heart.
• Increased systemic inflammation correlated with progressive symptoms, with p<0.05.