Skeletal muscle echo intensity measured by ultrasound was negatively correlated with sarcopenia indices (r = -0.56, p = 0.0096) and body weight (r = -0.50, p = 0.0233) among participants with obesity.
Observational
Blinded image analysis
Does skeletal muscle echo intensity measured by ultrasound accurately identify insulin resistance before changes in conventional markers?
Skeletal muscle echo intensity measured by ultrasound may serve as an early, noninvasive biomarker for insulin resistance independent of BMI and conventional glycemic markers.
Effect estimate: r = -0.56
p-value: p=0.0096
OBJECTIVES: To quantify the association between skeletal muscle echo intensity (MEI), measured by ultrasound, and clinical markers of insulin resistance and glycemic control, and evaluate MEI's diagnostic accuracy in identifying insulin resistance. METHODS: , 2-hour oral glucose tolerance testing with insulin for Matsuda Index), muscle ultrasound (deltoid, vastus lateralis), and DEXA for sarcopenia indices. Two blinded research assistants independently analyzed 336 ultrasound images to quantify MEI. RESULTS: and fasting glucose. Increased MEI in both muscles suggested global skeletal muscle changes. Among participants with obesity, MEI did not correlate with BMI but was negatively correlated with sarcopenia indices (r = -.56, p = .0096) and body weight (r = -.50, p = .0233). CONCLUSIONS: MEI is an accurate, noninvasive biomarker for insulin resistance and may detect muscle alterations before conventional markers emerge. Its independence from BMI and conventional markers supports MEI's use in early risk stratification and identification of individuals at risk for metabolic dysfunction who might otherwise go undetected.
Soliman et al. (Tue,) conducted a observational in Insulin resistance. Skeletal muscle echo intensity (MEI) by ultrasound vs. Conventional markers (HbA1c, fasting glucose) was evaluated on Correlation between MEI and sarcopenia indices among participants with obesity (r = -0.56, p=0.0096). Skeletal muscle echo intensity measured by ultrasound was negatively correlated with sarcopenia indices (r = -0.56, p = 0.0096) and body weight (r = -0.50, p = 0.0233) among participants with obesity.