Does the presence of atrial fibrillation and severe small vessel disease worsen 3-month functional outcomes and hematoma volume in patients with spontaneous intracerebral hemorrhage?
In patients with spontaneous intracerebral hemorrhage, the presence of atrial fibrillation, especially when combined with severe small vessel disease, synergistically worsens 3-month functional outcomes and increases hematoma volume.
Background: This study aimed to examine whether the presence of atrial fibrillation (AF), severity as judged by total small vessel disease (SVD) score, or a combination of these is associated with prognosis and hematoma volume of spontaneous intracerebral hemorrhage (sICH). Methods: This retrospective analysis investigated 608 patients who were admitted within 7 days of ICH onset between July 2012 and November 2023. The primary outcome was prognosis at 3 months after onset according to the modified Rankin Scale (mRS) score. Associations of AF, SVD and a combination of these with outcomes and hematoma volume were examined using univariate analyses, logistic regression analysis, and multiple regression analysis. Results: = 0.032). Conclusion: The presence of AF was associated with poor 3-month outcomes and increased estimated hematoma volume in sICH patients, whereas total SVD score alone was not. The effects of AF and SVD together appear to contribute synergistically to worsened prognosis and increased hematoma volume in sICH patients.
Hamada et al. (Wed,) studied this question.
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