Why the study?
Does nitroglycerin-potentiated head-up tilt testing have diagnostic and prognostic value in patients with suspected vasovagal syncope?
Population
369 patients with suspected vasovagal syncope, normal electrocardiogram, and no structural heart disease
Design
Cohort
Follow-up
mean 43 ± 27 months
Key result
Nitroglycerin-potentiated head-up tilt testing had a lower positivity rate in patients with likely versus established vasovagal syncope (36% vs 65%, P<0.0001), with similar long-term outcomes.
Authors
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Low yield in likely vasovagal syncope warrants cautious test interpretation; leaves open prognostic utility in suspected cases.
Observational (n=369)
Does nitroglycerin-potentiated head-up tilt testing have diagnostic and prognostic value in patients with suspected vasovagal syncope?
Absolute Event Rate: 65% vs 36%
p-value: p=<0.0001
Nitroglycerin-potentiated head-up tilt testing has a low diagnostic yield in patients with likely vasovagal syncope and does not predict long-term clinical outcomes.
Petix et al. (2013) conducted an observational in Suspected Vasovagal Syncope (n=369). Nitroglycerin-potentiated head-up tilt testing (HUT) vs. Established vs likely VVS was evaluated on Positivity rate of HUT (p=<0.0001). Nitroglycerin-potentiated head-up tilt testing had a lower positivity rate in patients with likely versus established vasovagal syncope (36% vs 65%, P<0.0001), with similar long-term outcomes.