Endocardial peak circumferential strain yielded better sensitivity and specificity in detecting MI compared to total wall thickness strain at 24 hours post-MI (P < 0.05), but not at 2 weeks.
Does layer-specific endocardial strain measurement improve the detection of MI extent compared to total wall thickness strain in acute vs chronic stages in a rat model?
Endocardial layer-specific strain analysis provides better sensitivity and specificity for detecting acute myocardial infarction extent than total wall thickness strain before significant remodeling occurs.
p-value: p=<0.05
Myocardial infarction (MI) injury extends from the endocardium toward the epicardium. This phenomenon should be taken into consideration in the detection of MI. To study the extent of damage at different stages of MI, we hypothesized that measurement of layer-specific strain will allow better delineation of the MI extent than total wall thickness strain at acute stages but not at chronic stages, when fibrosis and remodeling have already occurred. After baseline echocardiography scans had been obtained, 24 rats underwent occlusion of the left anterior descending coronary artery for 30 min followed by reperfusion. Thirteen rats were rescanned at 24 h post-MI and eleven rats at 2 wk post-MI. Next, rats were euthanized, and histological analysis for MI size was performed. Echocardiographic scans were postprocessed by a layer-specific speckle tracking program to measure the peak circumferential strain (S(C)(peak)) at the endocardium, midlayer, and epicardium as well as total wall thickness S(C)(peak). Linear regression for MI size versus S(C)(peak) showed that the slope was steeper for the endocardium compared with the other layers (P < 0.001), meaning that the endocardium was more sensitive to MI size than the other layers. Moreover, receiver operating characteristics analysis yielded better sensitivity and specificity in the detection of MI using endocardial S(C)(peak) instead of total wall thickness S(C)(peak) at 24 h post-MI (P < 0.05) but not 2 wk later. In conclusion, at acute stages of MI, before collagen deposition, scar tissue formation, and remodeling have occurred, damage may be nontransmural, and thus the use of endocardial S(C)(peak) is advantageous over total wall thickness S(C)(peak).
Bachner-Hinenzon et al. (Tue,) conducted a other in Myocardial infarction (n=24). Endocardial peak circumferential strain (S(C)(peak)) vs. Total wall thickness S(C)(peak) was evaluated on Sensitivity and specificity in the detection of MI using receiver operating characteristics analysis (p=<0.05). Endocardial peak circumferential strain yielded better sensitivity and specificity in detecting MI compared to total wall thickness strain at 24 hours post-MI (P < 0.05), but not at 2 weeks.
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