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The Hippo Pathway in Intestinal Regeneration, Fetal Reprogramming, and Tumorigenesis | Synapse

May 21, 2026

The Hippo Pathway in Intestinal Regeneration, Fetal Reprogramming, and Tumorigenesis

Key Points

This research investigates the role of the Hippo pathway in intestinal regeneration and its link to tumorigenesis.
Analyzed interactions between Hippo, WNT, TGF-β, and p53 signaling pathways.
Examined YAP regulation and its temporality in the context of intestinal repair and cancer development.
Dysregulated interactions in the Hippo pathway are associated with increased colorectal cancer risk.
Temporal control of YAP is crucial for effective regeneration of intestinal stem cells.

Abstract

) intestinal stem cells and epithelial integrity. Cross talk between Hippo, Wingless-related integration site (WNT), transforming growth factor β (TGF-β), and p53 signaling orchestrates this dynamic repair process, with precise temporal control of YAP essential for successful regeneration. Dysregulation of these interactions contributes to colorectal cancer tumorigenesis, highlighting the Hippo pathway as a central hub linking intestinal homeostasis, regeneration, and cancer.

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Cite This Study

Man et al. (Mon,) studied this question.

synapsesocial.com/papers/6a0ea074be05d6e3efb5f3cf https://doi.org/https://doi.org/10.1101/cshperspect.a041915