Transthoracic Doppler echocardiography parameters Δd ≥10 ms and E/Ea ≤14 predicted the discrepancy between elevated LVEDP and normal mean PCWP with 100% sensitivity and 85% specificity.
Observational (n=140)
No
Can transthoracic Doppler echocardiography predict the discrepancy between left ventricular end-diastolic pressure and mean pulmonary capillary wedge pressure in patients with heart failure?
Noninvasive transthoracic Doppler echocardiography can accurately predict the discrepancy between elevated LVEDP and normal PCWP, aiding in the early detection of elevated filling pressures in heart failure patients.
BACKGROUND: Left ventricular end-diastolic pressure (LVEDP) is difficult to measure continuously; therefore, pulmonary capillary wedge pressure (PCWP) is frequently used instead for hemodynamic monitoring in patients with heart failure. However, a discrepancy between LVEDP and mean PCWP is sometimes observed. METHODS AND RESULTS: To assess the feasibility of evaluating this discrepancy using echo-Doppler indexes, 140 consecutive patients with heart disease were studied. Transthoracic Doppler echocardiography (TTDE) was performed immediately before bilateral-sided cardiac catheterization. We measured peak velocities of early (E: cm/s) and late (A: cm/s) diastolic transmitral flow, and duration of A wave (MAd: ms). We also measured the duration of atrial reversal of pulmonary venous flow (PAd: ms). The difference between PAd and MAd (Deltad = PAd-MAd: ms) was calculated. The ratio of E to tissue Doppler-derived peak early diastolic velocity of mitral annulus (Ea: cm/s) was also calculated (E/Ea). There was a good positive correlation between LVEDP and Deltad (r = 0.77, p or = 10 ms and E/Ea or = 17 mmHg) and normal mean PCWP (< or = 12 mmHg) were predicted with 100% sensitivity and 85% specificity. CONCLUSIONS: Evaluation of the discrepancy between LVEDP and mean PCWP in patients with heart failure was feasible by separately estimating LVEDP by Deltad and mean PCWP by E/Ea using noninvasive TTDE. Early detection of patients with elevated LVEDP and normal mean PCWP may be useful for preventing acute exacerbation of chronic heart failure.
Hadano et al. (Sat,) conducted a observational in Heart failure (n=140). Transthoracic Doppler echocardiography (TTDE) vs. Invasive cardiac catheterization was evaluated on Prediction of elevated LVEDP (≥17 mmHg) and normal mean PCWP (≤12 mmHg) using Δd ≥10 ms and E/Ea ≤14. Transthoracic Doppler echocardiography parameters Δd ≥10 ms and E/Ea ≤14 predicted the discrepancy between elevated LVEDP and normal mean PCWP with 100% sensitivity and 85% specificity.