What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Congestive heart failure (n=150). Primary outcome: Predictors of medication adherence (p=0.018).

August 30, 2020Open Access

The relationship between medication adherence and affective temperaments in patients with congestive heart failure

ASAlireza ShamsiShahid Beheshti University of Medical Sciences HYHooria YavarmaneshZahedan University of Medical Sciences HHHani HaratiZahedan University of Medical Sciences

Key Result

Depression severity, but not affective temperaments, was identified as a significant predictor of medication adherence in patients with congestive heart failure.

Study Design

Type

Cross-Sectional (n=150)

Multicenter

Structured PICO

Population

150 patients with congestive heart failure referred to the cardiology clinic of Ali Ibn Abi Talib Hospital of Zahedan, Iran

Outcome

Relationship between medication adherence (measured by MMAS-8) and affective temperaments (measured by TEMPS-A) and depression (measured by BDI-II)patient reported

In patients with congestive heart failure, depression severity rather than affective temperaments is a significant predictor of medication adherence.

Main Result

p-value: p=0.018

Limitations

Use of available sampling methods for subject selection
Single-center study conducted in a cardiology clinic
Limited to patients with NYHA class II or III symptoms, which may not accurately reflect the entire CHF population

Abstract

Introduction: Congestive heart failure (CHF) is a serious condition and lack of medication adherence is one of the most common problems in the treatment of patients with CHF. This study aimed to determine the relationship between medication adherence and affective temperaments in patients with CHF. Material and methods: This cross-sectional study was performed on 150 patients, who were referred to the cardiology clinic of Ali Ibn Abi Talib Hospital of Zahedan, Iran in 2017–2018. Morisky Medication Adherence Scale (MMAS-8), Temperament Evaluation of Memphis, Pisa, Paris, and San Diego auto questionnaire (TEMPS-A), and Beck Depression Inventory-II (BDI-II) were used to collect data. For statistical analysis, SPSS-18 was used. Logistic regression was done for modeling the relationship between medication adherence. Results: Generally, 54% of the patients were euthymic, while 16%, 23.33%, and 6.66% of them suffered from mild, moderate, and severe depression, respectively. The medication adherence was high, moderate, and low in 30.66%, 46%, and 23.33% of the patients, respectively. There was a significant relationship between medication adherence and depressive (P = 0.049), cyclothymic (P = 0.01), and irritable (P = 0.01) affective temperaments. Only BDI-II score (P = 0.018) was identified as predictors of drug adherence. Conclusions: Despite the statistically significant relationship between depressive, cyclothymic, and irritable temperaments and adherence, affective temperaments cannot be considered as a predictor of adherence in patients with CHF.

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