Dabigatran 110 mg twice a day for 4 months resulted in complete resolution of a left ventricular thrombus in a 61-year-old male patient without any bleeding or embolic episodes.
Case Report (n=1)
No
Does dabigatran resolve left ventricular thrombus in a patient with hypertrophic cardiomyopathy?
Dabigatran may be an effective alternative for resolving left ventricular thrombus in patients who cannot tolerate warfarin.
Male patient in dilated phase of hypertrophic cardiomyopathy had multiple hospitalizations during the past 2 years either due to congestive heart failure, stroke, scar epilepsy, or atrial fibrillation and ventricular tachycardia. Medication included evidence based therapy for heart failure, cordarone and warfarin. Anticoagulation had to be discontinued due to marked fluctuations in INR. Transthoracic Echocardiography (TTE) revealed a mobile mass in the left ventricle. He was treated with Dabigatran 110mg twice a day for 4 months without any bleeding or embolic episode and complete resolution of thrombus. Dabigatran is a reversible direct thrombin inhibitor and currently approved for the prevention of thromboembolic episodes in non-valvar atrial fibrillation. This case demonstrates possible thrombolytic properties of dabigatran in resolution of left ventricular thrombus.
Kolekar et al. (Sat,) conducted a case report in Left ventricular thrombus (n=1). Dabigatran was evaluated on Resolution of left ventricular thrombus. Dabigatran 110 mg twice a day for 4 months resulted in complete resolution of a left ventricular thrombus in a 61-year-old male patient without any bleeding or embolic episodes.
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