Modified Framingham stroke risk profile and related research on uric acid in individuals aged over 65 years in the Yangtze River Delta region, China

Background: With socioeconomic advancement stroke has garnered extensive public attention. Aims: This study aimed to assess the 10-year risk of stroke among individuals aged over 65 years within a community utilizing the modified Framingham Stroke Profile (FSP). Additionally, the characteristics of high-risk factors for stroke and their associations with peripheral blood uric acid levels (UA) were explored. Methods: A cross-sectional stratified survey method was employed, adhering to the principles of stratified sampling. Between February and October 2020, residents from seven community committees in the Suzhou High-tech Zone were selected to participate in questionnaire surveys and undergo blood biomarker testing to evaluate the 10-year stroke risk of stroke using the modified FSP. Results: = 0.135). Logistic regression analysis identified several risk factors for modified FSP medium-high risk in the community-dwelling population aged over 65 years, comprising male sex, age, hyperlipidemia, and hyperuricemia in Q4. Moreover, receiver operating characteristic (ROC) curve analysis identified peripheral blood uric acid level as a potential predictor of high stroke risk, with an area under the ROC curve (AUC) of 0.611 (medium+high vs. low). Lastly, the optimal diagnostic threshold was 292.5 μmol/L (approximately 4.92 mg/dL). Conclusion: The stroke risk profile in this region warrants serious consideration. Elevated levels of uric acid (UA) are associated with increased modified FSP risk. Consequently, peripheral uric acid may serve as a limited indicator for discriminating medium-to-high modified FSP risk.