Testicular cancer survivors treated with cisplatin-based chemotherapy showed significantly increased vascular stiffness compared to those treated with orchiectomy alone (cf-PWV 8.39 vs 7.61 m/s).
Observational (n=197)
No
Does cisplatin-based chemotherapy increase vascular stiffness in long-term testicular cancer survivors compared to orchiectomy only or healthy controls?
Very long-term testicular cancer survivors treated with cisplatin-based chemotherapy exhibit accelerated vascular aging, highlighting the need for intensive cardiovascular risk management.
Absolute Event Rate: 8.39% vs 7.61%
p-value: p=<0.01
Abstract Background Late effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS. Methods TCS (treated with chemotherapy or orchiectomy only) and age-matched healthy controls were invited. Study assessment included vascular stiffness with ultrasound measurement of carotid-femoral pulse wave velocity (cf-PWV). Results We included 127 TCS consisting of a chemotherapy group (70 patients) and an orchiectomy group (57 patients) along with 70 controls. Median follow-up was 28 years (range: 20–42). The cf-PWV (m/s) was higher in TCS than in controls (geometrical mean 8.05 (SD 1.23) vs. 7.60 (SD 1.21), p = 0.04). The cf-PWV was higher in the chemotherapy group than in the orchiectomy group (geometrical mean 8.39 (SD 1.22) vs. 7.61 (SD 1.21), p < 0.01). In the chemotherapy group cf-PWV increased more rapidly as a function of age compared to controls (regression coefficient b 7.59 × 10 −3 vs. 4.04 × 10 −3 ; p = 0.03). Conclusion Very long-term TCS treated with cisplatin-based chemotherapy show increased vascular damage compatible with “accelerated vascular aging” and continue to be at risk for cardiovascular morbidity, thus supporting the need for intensive cardiovascular risk management. Clinical trial registration The clinical trial registration number is NCT02572934.
Stelwagen et al. (Mon,) conducted a observational in Testicular cancer (n=197). Cisplatin-based chemotherapy vs. Orchiectomy only and healthy controls was evaluated on Carotid-femoral pulse wave velocity (cf-PWV) (p=<0.01). Testicular cancer survivors treated with cisplatin-based chemotherapy showed significantly increased vascular stiffness compared to those treated with orchiectomy alone (cf-PWV 8.39 vs 7.61 m/s).