March 1, 1985

Testing the Statistical Certainty of a Response to Increasing Doses of a Drug

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Abstract

Experiments in which the treatments are composed of a series of doses of a compound and a zero dose control are often used in animal toxicity studies. A test procedure is proposed to assess trends in the response variable. The notion of a no-statistical-significance-of-trend (NOSTASOT) dose is introduced, and questions of multiplicity of statistical tests in this context are addressed.

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Tukey et al. (Fri,) studied this question.

synapsesocial.com/papers/6a11e9df0db2e61b4b8e1c59 https://doi.org/https://doi.org/10.2307/2530666

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