Aortic pulse wave velocity was a strong independent predictor of the presence of cardiovascular disease in subjects aged 70-100 years (adjusted OR 17.44; 95% CI 2.52-120.55).
Cohort (n=124)
Yes
Effect estimate: OR 17.44 (95% CI 2.52-120.55)
BACKGROUND: Aortic pulse wave velocity (PWV) is a significant and independent predictor of cardiovascular diseases (CVD) in hypertensive subjects and in patients with end-stage renal disease, but its contribution to cardiovascular risk in subjects between 70 and 100 years old has never been tested. PATIENTS: A cohort of 124 subjects (mean age: 87 +/- 7 years) was studied in two geriatric departments in a Paris suburb. Together with sphygmomanometric blood pressure measurements, aortic PWV was measured using a validated automatic device. RESULTS: Blood pressure, heart rate and body mass index, but not age, explained 48% of the PWV variability in this cohort. Furthermore, PWV was the major factor predicting the presence of CVD. The adjusted odds ratio was 17.44 (95% confidence intervals: 2.52-120.55). Antihypertensive drug therapy and low plasma albumin level had only an additive role. Blood pressure, particularly pulse pressure, had no predictive value. CONCLUSION: In 70-100-year-old subjects, aortic PWV is a strong independent marker of CVD, a finding that remains to be to confirmed by long-term longitudinal studies.
Meaume et al. (Tue,) conducted a cohort in Cardiovascular disease (n=124). Aortic pulse wave velocity was evaluated on Presence of cardiovascular disease (OR 17.44, 95% CI 2.52-120.55). Aortic pulse wave velocity was a strong independent predictor of the presence of cardiovascular disease in subjects aged 70-100 years (adjusted OR 17.44; 95% CI 2.52-120.55).