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-CAR T cells without upregulating exhaustion markers (PD-1/LAG3). These findings suggest that in the management of treatment-resistant pediatric solid tumors, utilizing chidamide during the manufacturing of CRISPR-engineered CAR T cells may enhance their persistence while retaining a naive phenotype.
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Dan Cappabianca
University of Wisconsin–Madison
Mahmoud Toulany
University of Wisconsin–Madison
Seth Zima
University of Wisconsin–Madison
University of Wisconsin–Madison
University of Wisconsin Carbone Cancer Center
Wisconsin Institutes for Discovery
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Cappabianca et al. (Tue,) studied this question.
synapsesocial.com/papers/6a129c49d83a8a9cd0a3ee8a — DOI: https://doi.org/10.1016/j.omton.2026.201200