Why the study?
Children with chronic kidney disease face excessive cardiovascular mortality and early cardiovascular alterations, but whether tissue Doppler imaging reveals reduced cardiac function compared to healthy children was unconfirmed.
Population
128 children aged 6–17 years with CKD and eGFR below 60 ml/min/1.73 m 2
Comparison
Cardiac tissue Doppler measurements vs published healthy reference data
Design
Cross-sectional echocardiographic study
Key result
Children with chronic kidney disease demonstrated significantly impaired diastolic function compared to healthy children, evidenced by a reduced tissue Doppler E'/A' ratio Z-score of -0.14 (p < 0.0001).
Authors
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May support cardiac screening in pediatric CKD; hypothesis-generating for prognostic value and interventions.
Cross-Sectional (n=128)
Yes
p-value: p=<0.0001
Tissue Doppler imaging reveals early subclinical systolic and diastolic left ventricular dysfunction in children with chronic kidney disease, which correlates with eGFR and blood pressure.
Doyon et al. (2019) conducted a cross-sectional in Chronic Kidney Disease (n=128). Chronic Kidney Disease vs. Healthy children (reference data) was evaluated on Tissue Doppler E'/A' ratio Z-score (p=<0.0001). Children with chronic kidney disease demonstrated significantly impaired diastolic function compared to healthy children, evidenced by a reduced tissue Doppler E'/A' ratio Z-score of -0.14 (p < 0.0001).